First a word of caution: If people speak about an unbounded operator from $X$ to $Y$, they mostly mean a (unbounded) linear map $T\colon D \rightarrow Y$, where $D$ is linear subspace of $X$ (see here). This allows to deal with differential operators in a context which is more general than that of polynomials. For example take $X=Y=L^2[0,1]$, $D=C^1[0,1]$ and $Tx=x'$ as before.
Of course you can always extend such a map $T\colon D \rightarrow Y$ to a linear map $\tilde T\colon X \rightarrow Y$ by simply setting $\tilde T\vert_{\tilde D} = 0 $ on some complementary subspace $\tilde D$ (i.e. a subspace with $X= D \oplus \tilde D$). This will also be unbounded, but does neither contain any new information nor respect the norm of $X$.
Using this notion of unbounded operators, at least on function spaces there is a huge class of examples, which generalizes differential operators. For the sake of simplicity let us consider $X=Y=L^2\mathbb{R}$.
1) Multiplication operators: Given $m\in L^1_{\text{loc}}\mathbb{R}$, put $D=\{x\in L^2\mathbb{R}\vert ~mx\in L^2\mathbb{R}\}$ and $Tx= mx$ for $x\in D$. This is a bounded operator iff $m$ is bounded.
2) Fourier Multiplication operators: The Fourier transform is a bounded linear map $F\colon L^2\mathbb{R} \rightarrow L^2\mathbb{R}$ (even an isometric isomorphism if you use the right normalization) and can be used to generate operators of the form
$$
Tx=F^{-1}\left(m\cdot(Fx)\right), \quad D=\{x\in L^2\mathbb{R}\vert~F^{-1}\left(m\cdot(Fx)\right) \in L^2\mathbb{R}\}
$$
Since $\Vert Tx \Vert = \Vert m \cdot (Fx)\Vert $ and $\Vert Fx\Vert = \Vert x \Vert$, this will again be bounded iff $m$ is a bounded function. Taking $m(\xi)=i\xi$ gives as assoicated operator exactly the differentiation operator $Tx=x'$.
3) Pseudodifferential operators: Take the same definition of $T$ as before, but allow $m$ to both depend on the spatial variable $t$ and the Fourier variable $\xi$. This generalizes the concepts above, $m(t,\xi)=m(t)$ gives a multiplication operator and $m(t,\xi)=m(\xi)$ gives a Fourier multiplication operator (see here for details).