An common application to ODE's is in physics. For example, you can add drag force in a calculation, whereas Newton's laws of constant acceleration do not:
$$s=ut+\frac{1}{2}at \tag{1}$$
Without drag, the differential equation for earth's gravity which would satisfy this is:
$$F=-F_g$$
$$m\frac{d^2 s}{dt^2}=-mg$$
$$\frac{d^2 s}{dt^2}=-g \tag{2}$$
This differential equation can be solved using various techniques, to derive equation $(1)$.
However, it gets more interesting when you do include drag force (air resistance) in your calculation.
The total force $F$ is given by:
$$F=-F_g+F_d$$
Where $F_g$ is the force due to gravity and $F_d$ is the force due to drag. We can apply our knowledge of forces to form the following differential equation:
$$m\frac{d^2 s}{dt^2}=-mg+k\left(\frac{ds}{dt}\right)^2 \tag{3}$$
Solving the above differential equation and applying appropriate initial conditions should give you the position of the falling object at any given point in time under air resistance by means of finding the unknown function $s(t)$.
These differential equations can be made to predict the weather such as temperature, by evaluating the function for $T(t)$ on a differential equation, where $T$ is the temperature and $t$ is the time.