Might be easiest to do this with the BoxSelect Feature in ISE.
In the editor, press alt+shift together to select the line at the mouse cursor position.
Then press up or down to add the same position to the line above or below the first line to the selection.
Example:
Line 1
Line 2
Line 3
If I place my cursor before line 1, press Alt+Shift and down arrow twice, I would select the same position on all 3 lines.
I could then comment out all 3 lines at once by pressing # to get:
#Line 1
#Line 2
#Line 3
Or I could press TAB instead of # to move all 3 lines at the same time:
Line 1
Line 2
Line 3
Alt+Shift and arrow key left or right will select portions of the 3 lines to copy, paste from clipboard or delete.