The event that fires when a frame loads is still under construction: https://github.com/hotwired/turbo/pull/59
The only events we currently have are turbo:before-fetch-request and turbo:before-fetch-response, that fire at the document level every time Turbo changes a frame or navigates pages. The content of the frame won't be loaded by the time the event fires, but it will allow you to potentially use the loaded property of the frame to hook up a promise that runs when the frame has loaded.
$(document).on("turbo:before-fetch-response", (e) ->
frame = document.getElementById("myFrame")
# Frame has finished loading
if frame.complete
#run my code
else
# Frame is still loading, run this code when it finishes
frame.loaded.then () ->
# run my code
Otherwise you can write a Stimulus controller that wraps your datepicker initialisation, so that you don't have to watch for it coming in and out of the DOM.