The isomorphism is incorrect. Althought I do come across some similar Sobolev spaces which is denoted by $\widetilde H^m(\Omega)$. It would be good if you can provide more details on where you see the usage of such mixed norm Sobolev spaces.
What you ask for is something called Fubini property of the function spaces. For convenience I just state the case for $d=2$, since for large you just take more intersections / sums.
For $1<p<\infty$, $k\ge0$ and for bounded Lipschitz domains $\Omega_1,\Omega_2$ we have
\begin{align*}
W^{k,p}(\Omega_1\times\Omega_2)&=L^p(\Omega_1;W^{k,p}(\Omega_2))\cap L^p(\Omega_2;W^{k,p}(\Omega_1));
\\
W^{-k,p}(\Omega_1\times\Omega_2)&=L^p(\Omega_1;W^{-k,p}(\Omega_2))+L^p(\Omega_2;W^{-k,p}(\Omega_1)).
\end{align*}
When I write papers I tend to use the language of strongly measurable vector-valued functions. When $p=1$, $L^1(\Omega_1;W^{k,1}(\Omega_2))=L^1(\Omega_1)\widehat\otimes_\pi W^{k,1}(\Omega_2)$ is the projective tensor.
In particular as tensor product of Hilbert spaces,
\begin{align*}
H^k(\Omega_1\times\Omega_2)&=L^2(\Omega_1)\widehat\otimes H^k(\Omega_2)\cap H^k(\Omega_1)\widehat\otimes L^2(\Omega_2);
\\
H^{-k}(\Omega_1\times\Omega_2)&=L^2(\Omega_1)\widehat\otimes H^{-k}(\Omega_2)+H^{-k}(\Omega_1)\widehat\otimes L^2(\Omega_2).
\end{align*}
When $\Omega_j=\mathbb R^{n_j}$ is the total spaces and $k\ge0$, see e.g. Hans Triebel, Theory Of Function Spaces Chapter 2.5.13. I don't have a good reference for the general case. I can write the proof down (or shameless cite my own paper) if you need.
Update: Anyway let me list a couple definitions here first. I have to say that I am not an expert as well, so there may be better references.
Let $(\Omega,\Sigma,\mu)$ be a measure space and let $X$ be a Banach space. We say a map $f:\Omega\to X$ is a simple function, if it is of the form $f=\sum_{j=1}^N\chi_{E_j}\otimes x_j$ in the senses that $f(\omega)=\sum_j\chi_{E_j}(\omega)\cdot x_j$, where $E_j\in\Sigma$ are measurable sets and $x_j\in X$.
Here we can define integral $\int_\Omega\sum_{j=1}^N\chi_{E_j}\otimes x_j d\mu=\sum_{j=1}^N\mu(E_j)\cdot x_j\in X$.
We say $f:\Omega\to X$ is strongly measurable, if it is a pointwise limit of a sequence of simple functions.
For $1\le p\le\infty$, the Bochner space $L^p(\mu;X)$ is the space of all stronly measurable $f$ such that $\|f\|_{L^p(\mu;X)}=(\int_\Omega\|f(\omega)\|_X^pd\mu(\omega))^{1/p}<\infty$, quotient of $\mu$ almost everywhere zero functions. Here in the case $p=\infty$ we use $\|f\|_{L^\infty(\mu;X)}=\inf\{r>0:\mu\{\omega:\|f(\omega)\|>r\}=0\}$.
The Fubini theorem states that for $1\le p<\infty$, $L^p(\Omega_1\times\Omega_2)=L^p(\Omega_1;L^p(\Omega_2))=L^p(\Omega_2;L^p(\Omega_1))$.
See for example Analysis in Banach spaces. Vol. I. Section 1.2. However this is not true for $p=\infty$.
In the case $p=\infty$ we have $L^\infty(\Omega_1;L^\infty(\Omega_2))\subsetneq L^\infty(\Omega_1\times\Omega_2)$. A typical example is $\chi_{\mathbb R_+}(x-y)$ for $x,y\in\mathbb R$.
If you really need to work with $p=\infty$, then one should use $L^\infty(\Omega_1\times\Omega_2)=\mathscr L(L^1(\Omega_1);L^\infty(\Omega_2))$, in the sense we identify $K(x,y)\in L^\infty_{x,y}$ with $T^K:L^1(\Omega_1)\to L^\infty(\Omega_2)$ by $T^Kg(y)=\int_{\Omega_1}K(x,y)g(x)dx$. See Delio Mugnolo & Robin Nittka (2010) Properties of representations of operators acting between spaces of vector-valued functions for a general servey.
We can define vector-valued Sobolev spaces $W^{k,p}(\Omega;X)$ in a similar way. I refer to Analysis in Banach spaces. Vol. I. Section 2.5.
If you use the following norm definition $\|f\|_{W^{k,p}(\Omega;X)}^p=\sum_{|\alpha|\le k}\|\partial^\alpha f\|_{L^p(\Omega;X)}^p$. Then for $1\le p\le\infty$ and $k\ge0$,
\begin{equation*}
W^{k,p}(\Omega_1\times\Omega_2)=\bigcap_{j=0}^kW^{j,p}(\Omega_1;W^{k-j,p}(\Omega_2))\text{ with }\|f\|_{W^{k,p}(\Omega_1\times\Omega_2)}^p=\sum_{j=0}^k\|f\|_{W^{j,p}(\Omega_1;W^{k-j,p}(\Omega_2))}^p.
\end{equation*}
I don't have a good reference for the above equality and I proved it myself in an ongoing paper.
Next let's turn to tensor products. On vector spaces it is a bad idea to refer to universal property. Instead one should think of the idea that tensor of two vectors becomes a matrix.
Given two Banach spaces $X$ and $Y$, the projective tensor space $X\widehat\otimes_\pi Y$ is the closure of the algebra tensor space $X\otimes Y$ under the norm
$$\|f\|_{X\widehat\otimes_\pi Y}=\inf\Big\{\sum_{j=1}^\infty\|x_j\|_X\|y_j\|_Y:f=\sum_{j=1}^\infty x_j\otimes y_j\Big\}.$$
The projective tensor can be defined by the universal property via the category of Banach spaces.
However there is a different space called injective tensor space $X\widehat\otimes_\epsilon Y$, which is the closure under the norm
$$\|f\|_{X\widehat\otimes_\epsilon Y}=\sup\Big\{\sum_{j=1}^\infty \phi(x_j)\psi(y_j):f=\sum_{j=1}^\infty x_j\otimes y_j,\quad\phi\in X',\psi\in Y',\ \|\phi\|_{X'}=\|\psi\|_{Y'}=1\Big\}.$$
We always have $X\widehat\otimes_\pi Y\subset X\widehat\otimes_\epsilon Y$. For infinite dim Banach spaces they are never equal. In most cases (say $X$ and $Y$ reflexive) we have $(X\widehat\otimes_\pi Y)'=X'\widehat\otimes_\epsilon Y'$.