The title pretty much explains it, but let's provide more context:
Say we have a rational function $R(x)$ of degree $\le -2$. Then the series $\sum_{n\ge n_0} R(n)$ is convergent. The sum is very easy to evaluate if $R(x)$ happens to be a discrete difference: $$R(x) = S(x)-S(x+1)$$ for another rational fraction $S(x)$ of degree $\le -1$. There are some necessary and sufficient conditions for that, see for instance this question.
Recently there was another question on the site where some answers provided examples of series $\sum_{n\ge 1} R(n)$ with a rational sum, and $R(x)$ a rational fraction in $\mathbb{Q}(x)$. In all of the examples the sum was calculated using the fact that $R(x)$ is a discrete difference. Now the question whether there could not exist an example of a series as above with a rational sum where $R(x)$ is not a discrete difference.
Note that if the denominator of $R(n)$ has all roots integers such an example would (probably) not be possible, as this would imply some rational dependence among values of the zeta function at positive integers. We know that this is not possible for the values at even integers ( equivalent to $\pi$ is transcendental), and I do not expect that the all zeta values and $1$ would be linearly dependent over $\mathbb{Q}$. So an example would involve some other fractions. Would be happy to see an example, maybe a very simple one, that escapes me at the moment. Thank you for your interest!
$\bf{Added:}$ Calvin Lin just provided a very ingenious answer, using zeta sums at odd integers! While the question is thus answered, one could think what else is out there... " can you surprise me with a series $\sum_{n\ge 1} R(n) \in \mathbb{Q}$ in other ways ?"
$\bf{Added:}$ Building on the idea of Calvin Lin:
Say $T(n) = \frac{1}{n^k}$, $k>1$, then for $d\ge 2$ integer we have
$$\frac{1}{d^k} \sum_{n\ge 1} T(n) = \sum_{n\ge 1} \frac{1}{(d n)^k}=\sum_{n\equiv 0 \mod d} T(n)$$
and so $$(1-\frac{1}{d^k}) \sum_{n\ge 1} T(n) = \sum_{n\not \equiv 0 \mod d} T(n)$$
or
$$\sum_{n\ge 1}\left[ (1-\frac{1}{d^k}) T(n) - ( T(d(n-1) + 1) + T(d(n-1) + 2) + \cdot T(d(n-1) +(d-1)) ) \right] = 0$$
We could do other similar things. Let $p_1$, $p_2$, $\ldots$ $p_i$ be the prime factors of some $d\ge 2$ natural. Then we have
$$(1-\frac{1}{p_1^k})(1-\frac{1}{p_2^k}) \cdots (1-\frac{1}{p_i^k}) \sum_{n\ge 1}\frac{1}{n^k} - \sum_{(n,d) = 1} \frac{1}{n^k} = 0$$
and again we get an example. Note that we do get a series that is not a difference.