I feel like I understand the general idea behind how Gödel used self-reference to prove that there will always be holes in logical systems, even if you add the self-referential statement to the axioms because you can always create another statement that is true but cannot be proven via Cantor's diagonalization proof. I am confused as to why this implies that other statements, like the twin primes and Goldbach conjectures could also be true but not have proofs. These statements are not self-referential. Do we have proof of any true statement that cannot be proven true in mathematics that isn't self-referential? If not, then why is Gödel's incompleteness Theorem relevant outside of the one case he found?
Edit: I am reading Gödel Escher Bach, and therefore my understanding might be skewed.