Let $ A,B $ be matrix groups (with entries in the same field). Then the tensor/Kronecker product $ A \otimes B $ is a matrix group and $$ \pi: A \times B \to A \otimes B $$ is a group homomorphism. Taking $ A=B=SU_2 $ we have a map $ \pi: SU_2 \times SU_2 \to SU_4 $ given by $$ (A,B) \mapsto A \otimes B $$ The only nontrivial element of the kernel is $ (-1,-1) $. So the image $ SU_2 \otimes SU_2 $ of $ \pi $ is a subgroup of $ SU_4 $ isomorphic to $$ SU_2 \times SU_2/ (-1,-1) \cong SO_4(\mathbb{R}) $$
Is $ SU_2 \otimes SU_2 $ conjugate to $ SO_4(\mathbb{R}) $ in $ SU_4 $? If so what is a matrix conjugating one to the other? (this part was unanswered for a while but is now answered in the update)
Since matrices in $ SU_2 $ have real trace then all matrices in $ SU_2 \otimes SU_2 $ have real trace. So it is at least plausible that $ SU_2 \otimes SU_2 $ and $ SO_4(\mathbb{R}) $ are conjugate.
Also what is the normalizer in $ SU_4 $ of $ SU_2 \otimes SU_2 $ / the normalizer in $ SU_4 $ of $ SO_4(\mathbb{R}) $? Certainly $ iI $ normalizes $ SO_4(\mathbb{R}) $ and $$ T= \zeta_8 \begin{bmatrix} 1 & 0 & 0 & 0\\ 0 & 0 & 1 & 0\\ 0& 1 & 0 & 0 \\ 0 & 0 & 0 & 1 \\ \end{bmatrix} $$ normalizes $ SU_2 \otimes SU_2 $.
EDIT: Just to reiterate what Jason DeVito both $ SO_4(\mathbb{R}) $ and $ SU_2 \otimes SU_2 $ are normalized by $$ T= \zeta_8 \begin{bmatrix} 1 & 0 & 0 & 0\\ 0 & 0 & 1 & 0\\ 0& 1 & 0 & 0 \\ 0 & 0 & 0 & 1 \\ \end{bmatrix} $$ where $$ \begin{bmatrix} 1 & 0 & 0 & 0\\ 0 & 0 & 1 & 0\\ 0& 1 & 0 & 0 \\ 0 & 0 & 0 & 1 \\ \end{bmatrix}=SWAP \in O_4(\mathbb{R}) $$ is the $ SWAP $ operator and $ \zeta_8 $ just normalizes the determinant. Both $ SO_4(\mathbb{R}) $ and $ SU_2 \otimes SU_2 $ contain $ -I $ and both do not contain $ iI $. Since \begin{align*} (\zeta_8 SWAP)^2&=iI\\ (\zeta_8 SWAP)^4&=-I \end{align*} we can combine this with the results from https://arxiv.org/pdf/math/0605784.pdf to conclude that both $ SO_4(\mathbb{R}) $ and $ SU_2 \otimes SU_2 $ have cyclic $ 4 $ component group generated by $ \zeta_8 SWAP $.