I think if we have at least one
$$
u \in \bigg( \mathbb R \backslash \bigg\{ \frac \beta {2(\alpha + 2y)} \bigg\} \bigg) \cup (i\cdot \mathbb R)
$$
that solves the original quartic equation, the answer is yes, i.e. $\alpha + 2y \ge 0$. For the purpose of the question, where only real solutions $u$ are searched for, that statement is enough:
- calculate all extreme points of the original quartic equation (solving cubic equations is possible with only real numbers involved)
- If all extreme points are positive, there are no real solutions $u$. If at least one extreme point is non-positive, there are real solutions $u$. Then the above statement tells us that the quartic equation can be solved with only real numbers involved.
However, this strategy looks complicated, so further answers are appreciated!
Proof:
Let us fix such a $u$. Then $u^2 \in \mathbb R$. Due to Wikipedia (equation (5)), our setting implies
$$
\bigg( \sqrt{\alpha + 2y} u - \frac {\beta} {2\sqrt{\alpha + 2y}} \bigg)^2
=
(u^2 + \alpha + y)^2
\in
[0;\infty)
$$
This implies
$$
\sqrt{\alpha + 2y} u - \frac {\beta} {2\sqrt{\alpha + 2y}}
\in
\mathbb R
$$
Now assume $\alpha + 2y < 0$. Then
$$
\sqrt{\alpha + 2y}, \frac \beta {2\sqrt{\alpha + 2y}} \in i \cdot \mathbb R
$$
If $u \in \mathbb R$, then we obtain
$$
0
=
\sqrt{\alpha + 2y} u - \frac {\beta} {2\sqrt{\alpha + 2y}}
\Rightarrow
u
=
\frac \beta {2(\alpha + 2y)},
$$
a contradiction.
If $u \in i \cdot \mathbb R$, then we obtain $\sqrt{\alpha + 2y} u \in \mathbb R$ and hence $\beta = 0$, which is also a contradiction to the original assumption.