Firstly a small disclaimer. I am not an expert in the theory of higher sheaves and their presentation in the model categories, so please feel free to correct all inaccuracies in the question itself!
Assume we have two presheaves on the $1$-site of topological spaces (equipped with the structure of the model category) $\mathsf{F}, \mathsf{G}: \mathsf{Top} \to \mathsf{C}$ which take values in an ambient model category $\mathsf{C}$, which is homotopy-complete model cateogory. Further assume that they both satisfy Čech homotopy descent condition, namely that there are weak equivalences $\mathsf{F}(X) \tilde{\rightarrow} \mathsf{holim}(\mathsf{F}(\mathsf{Č}(\mathfrak{U} \to X)_\bullet))$ and $\mathsf{G}(X) \tilde{\rightarrow} \mathsf{holim}(\mathsf{G}(\mathsf{Č}(\mathfrak{U} \to X)_\bullet))$, where $\mathsf{Č}(\mathfrak{U} \to X)_\bullet$ is the Čech nerve of any covering $\mathfrak{U} \to X$. To say it differently, they are supposed to be sheaves in some sense convenient for the homotopy theory. A good reference for this might be https://arxiv.org/abs/math/0205027 from Dugger, Hollander and Isaksen, where they consider $\mathsf{C} = \mathsf{sSet}$. However, my favourite category $\mathsf{C}$ is $\mathsf{DGCA}$, the category of differential graded commutative algebras with its model structure.
Question: What is a suitable notion of a natural transformation between $\mathsf{F}$ and $\mathsf{G}$? Can we get any component $\alpha_X: \mathsf{F}(X) \to \mathsf{G}(X)$ of this natural transformation from series of components $\{\alpha_{\mathsf{Č}(\mathfrak{U} \to X)_k}: \mathsf{F}(\mathsf{Č}(\mathfrak{U} \to X)_k) \to \mathsf{G}(\mathsf{Č}(\mathfrak{U} \to X)_k) \}_{k \in \mathbb{N}}$? If so, what are coherence relations between these components?
It tempts me to think about higher category theory generalisation of a natural transformation between $n$-functors, but I can not find any reference for it neither being able to find an answer by myself.