Let $M,M'$ be homeomorphic smooth, closed, simply connected 4-manifolds. Is it necessarily true that $w_2(TM)=w_2(TM')$ and $p_1(TM)=p_1(TM')$? If so, the comment on this post, shows that $TM$ and $TM'$ are topologically isomorphic as vector bundles.
If the above is false, how does the statement fail, i.e. do we have $w_2(TM)\neq w_2(TM')$, or $p_1(TM)\neq p_1(TM')$, or both?