Let $R \subset S$ be commutative rings with unity. The usual definition for an element $x \in S$ to be integral over $R$ is to require the existence of a monic polynomial with coefficients in $R$ such that $x$ is a root of that polynomial.
Why is it that we define it by the use of monic polynomials? Clearly, if an element is integral within this definition, it would also be integral if we would not require the polynomial to be monic. On the other hand, if an element would be the root of a polynomial with leading coefficient not a unit, it wouldn't be integral.
Furthermore, if we denote by $K$ the integral closure of $R$ according to the definition given above, and by $\tilde{K}$ we denote the "alternative integral closure" of $R$ (i.e. the set of all elements $x \in S$ s.t. there exists a polynomial - not necessarily monic - with coefficients in $R$ that vanishes at $x$) we get the relation
$$R\subset K \subset \tilde{K} \subset S$$
But why is $\tilde{K}$ apparently of less interest than $K$? After all, $\tilde{K}$ is not always equal to $S$, take e.g. $k\left[x\right] \subset k\left[x,y\right]$ for a field $k$ and consider the element $y \in k\left[x,y\right]$. Clearly, when talking about field extensions (i.e. about algebraic elements instead of integral ones) the sets $K$ and $\tilde{K}$ become equivalent. But it seems to me that in the case of general commutative rings the study of $\tilde{K}$ could also be of interest and lead to results worthwhile in their own rights.
EDIT
I just realised that in the case of finite field extensions we might lose uniqueness of the minimal polynomial. Is this indeed the case? My assumption comes from the fact that when proving by contradiction, assuming there exist $p \neq q \in K\left[x\right] \subset L\left[x\right]$ both minimal of degree $n$, then $p-q$ is of strictly less degree but still vanishes at the element in question. This proof wouldn't work if the polynomials aren't required to be monic (the degree would not decrease necessarily). Maybe there is something similar to rings that we would loose?