If I understand the continuum hypothesis (and its undecidability) correctly, then one can safely assert the existence of some set $A$ whose cardinality is between that of the integers and that of the real numbers, and this assertion will not cause a contradiction within ZFC set theory.
Have such sets ever been useful within mathematics or physics? I'll leave "useful" up to your own interpretation, but here are some examples of what I mean:
The assumption that there exists a type of number whose square is $-1$ led to complex analysis, which has been useful in both pure math and applied physics.
The rejection of Euclid's 5th postulate led to non-Euclidean geometry, which was also useful in both math and physics.
Some starting criteria for "useful" might be:
- Launching a new field of math
- Shedding new light on existing fields of math
- Helping prove something that was already an open question
- Playing any role in theoretical physics or some other field