Commutative $AW^*$-algebra are characterized as those $C^*$-algebras such that their space of projections is a complete boolean algebra (see http://en.wikipedia.org/wiki/AW*-algebra).
Von Neumann algebras are characterized as those $C^*$-subalgebras $A$ of $B(H)$ satisfying any of these three equivalent conditions - see section 4.6 in Pedersen's book "Analysis Now" (specifically Theorem 4.6.7 and Proposition 4.6.15):
$A$ overlaps with its double commutant $A''$ (where $A'=\{T:ST=TS \, for \, all \, S\in A\}$).
$A$ is weakly closed ($A$ is closed in the topology generated by the seminorms $T\mapsto |(Tx,y)|$ for $x,y\in H$).
$A$ is $\sigma$-weakly closed ($A$ is closed in the topology generated by by the seminorms $T\mapsto |\sum_n(Tx_n,y_n)|$ for $x_n,y_n\in H$ such that $\sum \|x_n \|,\sum\|y_n\|<\infty$).
Let now for example $A$ be the commutative $AW^*$-algebra given by $[f]_I$ with $f:\mathbb{R}\to\mathbb{C}$ Borel and bounded and $I$ the ideal generated by functions with meager support. It is shown in Tristan Bice's answer to Examples of hyperstonean space that this $AW^*$-algebra does not carry normal positive functionals and thus it is not a Von Neumann algebra. However $A$ is a $C^*$-algebra so (By the GNS-construction) it has an isomorphic copy as a $C^*$-subalgebra of $B(H)$ (It may be the case that $H$ is a non-separable Hilbert space though, but I don't think this matters in what follows). Where does the double commutant Theorem (4.6.7) fails for this $AW^*$-subalgebra of $B(H)$? I'm a bit puzzled - I can expect that there is a problem with $\sigma$-weakly continuous functionals, but I don't see where the problem can arise with weakly continuous functionals.
And yes, I think you're on the right track with your other thoughts but again you don't need to restrict to commutative AW*-algebras/extremally disconnected spaces.
– Tristan Bice Apr 13 '15 at 19:47