(The OP suggested a connection to this post.)
Because this question is too broad, it spreads thin and may be vague. I suggest it be limited so coefficients $a_i$ are rational, and $x,y$ are also rational.
Having said that, two nice results are discussed in Kevin Brown's website.
I. Deg 2: The sum of $24$ consecutive squares.
$$F(x) = x^2+(x+1)^2+(x+2)^2+\dots+(x+23)^2=y^2\tag1$$
$$F(x) = 24x^2+552x+4324=y^2$$
which has solution,
$$x=p^2+70pq+144q^2,\quad\quad y =10(7p^2+30pq+42q^2)$$
where $p,q$ solve the Pell equation $p^2-6q^2=1$. This has an infinite number of integer solutions with the case $p,q = 1,0$ yielding the famous cannonball stacking problem,
$$1^2+2^2+3^2+\dots+24^2 =70^2$$
II. Deg 3: The sum of $n$ consecutive cubes.
$$G(x) = x^3+(x+1)^3+(x+2)^3+\dots+(x+n-1)^3=y^3\tag2$$
$$G(x) = n x^3 + \tfrac{1}{4}n(n - 1)\big(6x^2 + 4 n x - 2x + n(n - 1)\big) =y^3$$
a solution of which (by Dave Rusin) is,
$$x=\tfrac{1}{6}(v^4 - 3v^3 - 2v^2 + 4),\quad\quad n=v^3$$
hence for $2^3=8$ and $4^3=64$ cubes,
$$(-2)^3+(-1)^3+\dots+3^3+4^3+5^3 = 6^3$$
$$6^3+7^3+8^3+9^3+10^3+\dots+69^3 = 180^3$$
and so on.
III. Deg 4: The sum of 4th powers in arithmetic progression.
No analogous results known so far. See linked post in first line.