Yes. You can show it as follows:
A field $K(t)$ which is a purely transcendental extension of another field $K$ of characteristic zero admits a nontrivial $K$-linear derivation $\frac{\partial}{\partial t}$ defined by $\frac{\partial}{\partial t} t = 1$; this gives $\frac{\partial}{\partial t} q(t) = q'(t)$ where $q(t) \in K(t)$ is a rational function and $q'(t)$ is its formal derivative.
If $K$ is a field with a derivation $D$ and $L/K$ is a separable algebraic extension of $K$, then $D$ extends uniquely to a derivation on $L$.
The first claim is straightforward. For the second claim we can reduce to the case of an extension $K[\alpha]/f(\alpha)$ generated by an algebraic element $\alpha$ with separable minimal polynomial $f(\alpha)$. Then if $D$ is our derivation we have $f(\alpha) = 0$ so
$$D f(\alpha) = f'(\alpha) D(\alpha) = 0$$
(this is a "chain rule" for derivations), and since $f'(\alpha) \neq 0$ by separability this forces $D(\alpha) = 0$, and then we can check that this defines an extension of $D$ to $L$.
This second property turns out to be an if-and-only-if characterization of separable extensions; see e.g. Theorem 1.5 in these notes by Keith Conrad.
Corollary: Every field of characteristic zero $K$ containing a transcendental element $t$ admits a derivation $D : K \to K$ such that $D(t) = 1$. If $K$ is an algebraic extension of $\mathbb{Q}$ then it admits no nonzero derivations.
This is because every such field $K$ is a separable (since we are in characteristic zero) extension of a purely transcendental extension of $\mathbb{Q}$, corresponding to a transcendence basis.
So, for example, $\mathbb{R}$ admits a derivation one might call $\frac{\partial}{\partial \pi}$ such that $\frac{\partial}{\partial \pi} \pi = 1$. Whether this is useful for anything is unclear; to construct this derivation requires a transcendence basis of $\mathbb{R}$ over $\mathbb{Q}$ containing $\pi$ which requires the axiom of choice. The construction of the derivation depends on this choice (since you need to specify what the derivation does to other elements of $\mathbb{R}$ and in particular other transcendentals, which can be done arbitrarily on a transcendence basis) and is highly non-unique.
By working a little harder we should be able to show that a derivation on a field $K$ of characteristic zero is completely determined by what it does to a transcendence basis of $K$, and can take arbitrary values on such a basis.