It is a well-known (but not easy) fact that a (topological) embedding of the $0$-dimensional sphere $S^0 = \{-1, 1\}$ in a path connected Hausdorff space $X$ extends to an embedding of the $1$-dimensional closed unit disk $D^1 = [-1, 1]$; see Corollary 31.6 of [Willard] or the post Equivalence of Path-Connectedness and Arc-Connectedness for Hausdorff Spaces.
Let's assume $X$ is Hausdorff and simply connected, which means $X$ is path connected and every continuous map $S^1 \to X$ extends to a continuous map $D^2 \to X$. The existence of non-trivial knots in $S^3$ shows an embedding $S^1 \to S^3$ need not extend to an embedding $D^2 \to S^3$; this innocent statement encapsulates more difficulties than one might imagine. It seems too good to be true, so I guess it's also false in general that an embedding $S^1 \to X$ extends to a locally injective continuous map $D^2 \to X$. Question: What is an example of such $X$ and $S^1 \to X$?
For context, if there were no counterexamples, I think this would salvage a more restricted version of my previous question Can the real plane $\mathbb{R}^2$ with a topology strictly finer than the Euclidean topology be simply connected? (by providing a negative answer in the case that the topology is Euclidean outside of a bounded set).
Willard, Stephen, General topology, Mineola, NY: Dover Publications (ISBN 0-486-43479-6/pbk ). xii, 369 p. (2004). ZBL1052.54001.