Suppose that $X$ is a locally compact normal noncompact Hausdorff space. In particular, $X$ is completely regular and, hence, the canonical embedding $\iota: X\to \beta X$ from $X$ to its Stone–Čech compactification, is a topological embedding with open image (which I will identify with $X$ itself). I claim that $\beta X$ cannot be path-connected, moreover, there is no continuous path connecting any point $x\in X$ to any point $y\in Y:=\beta X\setminus X$. Indeed, suppose such path exist. Then, since $X$ is open in $\beta X$, without loss of generality, we can assume that such a path has the form $p: [0,1]\to \beta X$, $p([0,1))\subset X$, $p(1)=y\in Y$. Then $p: [0,1)\to X$ is a proper map. Consider two sequences $s_n, t_n\in [0,1)$ converging to $1$ and having disjoint images $A$ and $B$ respectively. After passing to subsequences, we can assume that $p$ is injective on the images of $(t_n)$ and $(s_n)$. By the construction, $A\cup B$ is closed in $X$. Define a continuous map $g: A\cup B\to [0,1]$ by
$$
g(p(s_n))= s_n, g(p(t_n))=1-t_n.
$$
Since $X$ was assumed to be normal, by Tietze–Urysohn extension theorem, $g$ extends to a continuous map $f: X\to [0,1]$. By the universal property of the
Stone–Čech compactification, the map $f$ extends to a continuous map $F: \beta X\to [0,1]$. Since $p$ was a continuous map and
$$
\lim_{n\to\infty} p(s_n)= \lim_{n\to\infty} p(t_n)=y,
$$
we have
$$
\lim_{n\to\infty} F(p(s_n))= \lim_{n\to\infty} F(p(t_n))= F(y).
$$
However, by the construction, $F(p(s_n))=s_n, F(p(t_n))=1-t_n$ and, thus, these sequences have distinct limits in $[0,1]$ (respectively, $1$ and $0$).
This is a contradiction. Hence, $\beta X$ is not path-connected. This answers half of your question.
The answer to the second half is in my earlier comment, here it is for the sake of completeness.
Let $X$ be any topological space. Define a new topological space $Y=X\sqcup \{a\}$ where open subsets in $Y$ are either open subsets of $X$ or (if they contain $a$) are equal to the entire $Y$. Of course, $Y$ is only Hausdorff if $X=\emptyset$. Nevertheless, $Y$ is a compactification of $X$: Clearly every open cover of $Y$ contains $Y$ as one of its elements, hence, admits a finite subcover. Furthermore, the inclusion $X\to Y$ is a homeomorphism to its image and the image is dense in $Y$. I claim that $Y$ is contractible, hence, simply-connected. Indeed, define a map $H: Y\times [0,1]\to Y$ by $H(y,t)=y$, $t<1$ and
$H(y,1)=a$ for all $y\in Y$. Let's check that this map is continuous: If $U\subset X$ is open, then $H^{-1}(U)=U\times [0,1)$. If $U=Y$, then $H^{-1}(U)=Y\times [0,1]$. And there are no other open subsets of $Y$. Hence, $H$ is continuous.
Edit. The true question, I think, is about existence of a compactification with is path-connected but not simply-connected. However, one can prove that $[0,1)$ does not have one.