I know that if $H$ is a complete group (meaning that the homomorphism $H\to\text{Aut}(H)$ is an isomorphism) and if $H$ is not perfect (meaning that $H^\prime\lneq H$) then $H$ is not the derived subgroup of any group. In particular, if $n\geq3$ and $n\neq6$ then $S_n$ is not the derived subgroup of any group. Clearly $S_1$ and $S_2$ are both the derived subgroup of some group.
Is $S_6$ the derived subgroup of some group?
A natural choice would be $\text{Aut}(S_6)$ since $S_6$ is a normal subgroup of index 2. Unfortunately, $A_6$ is a normal subgroup of index 4 so $\text{Aut}(S_6)^\prime\leq A_6$.