Quoted from https://cstheory.stackexchange.com/a/27695/48912:
Here I show that the problem is NP-complete.
We convert a CNF to an instance of your problem as follows. Suppose
that the variables of the CNF are $n$ $x_i$'s and the clauses are $m$
$C_j$'s, where $n<m$. Let $U=\cup_i (A_i\cup B_i\cup Z_i)$ where all
sets in the union are completely disjoint. In fact, $A_i=\{a_{i,j}\mid
x_i\in C_j\}\cup\{a_{i,0}\}$ and $B_i=\{b_{i,j}\mid x_i\in
C_j\}\cup\{b_{i,0}\}$, while $Z_i$ is any set of cardinality $k=2n+1$.
Also denote $Z=\cup_i Z_i$ and fix for every $Z_i$ an increasing
family of length $k$ inside it, denoted by $Z_{i,l}$ for $l=1..k$. For
every variable $x_i$, we add $2k$ sets to $\mathcal F$, every set of
the form $A_i \cup Z_{i,l}$ and $B_i \cup Z_{i,l}$. For every clause
$C_j$, we add one set to $\mathcal F$, which contains $Z$, and for
every $x_i\in C_j$ element $\{a_{i,j}\}$ and for every $\bar x_i\in
C_j$ element $\{b_{i,j}\}$.
Suppose that the formula is satisfiable and fix a satisfying
assignment. Then pick the $k$ sets of the form $A_i \cup Z_{i,l}$ or
$B_i \cup Z_{i,l}$, depending on whether $x_i$ is true or not. These
are $nk$ incremental sets. Now add the $m$ sets corresponding to the
clauses. These also keep increasing the size, as the clauses are
satisfiable. Finally, we can even add $k$ more sets (one for each
variable) to make the sequence cover $U$.
Now suppose that $n(k+1)+m$ sets are put in an incremental sequence.
Notice that at most $k+1$ sets corresponding to $x_i$ can be selected
for each $x_i$. Thus, if there are no clause sets in the incremental
sequence, at most $n(k+1)$ can be selected, which is too few. Notice
that as soon as a clause set is selected, we can pick at most two sets
corresponding to each $x_i$, a total of at most $2n$ sets. Therefore,
we have to pick at least $n(k-1)$ variable sets before any clause set
is picked. But as we can pick at most $k+1$ for each $x_i$, this means
that for each we have picked at least $1$, as $k=2n+1$. This
determines the "value" of the variable, thus we can pick only "true"
clauses.